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Preventive catheter ablation for ventricular arrhythmias in patients with end-stage heart failure referred for heart transplantation evaluation: Rationale for and design of the CASTLE-VT trial
European Journal of Heart Failure ( IF 16.9 ) Pub Date : 2024-11-11 , DOI: 10.1002/ejhf.3512
Christian Sohns, Thomas Fink, Harry J.G.M. Crijns, Angelika Costard-Jaeckle, Nassir F. Marrouche, Samuel Sossalla, Rene Schramm, Mustapha El Hamriti, Maximilian Moersdorf, Maxim Didenko, Martin Braun, Vanessa Sciacca, Frank Konietschke, Volker Rudolph, Jan Gummert, Jan G.P. Tijssen, Philipp Sommer

Timely referrals for transplantation and left ventricular assist device (LVAD) play a key role in favourable outcomes in patients with advanced heart failure (HF). Cardiovascular mortality, driven by sudden cardiac death, is the main reason for dying while waiting for heart transplantation (HTx). The purpose of the Preventive Catheter Ablation for ventricular arrhythmiaS in patients with end-sTage heart faiLure rEferred for heart transplantation eValuaTion (CASTLE-VT) trial is to test the hypothesis that prophylactic catheter ablation of arrhythmogenic ventricular scar tissue will reduce mortality, need for LVAD implantation, and urgent HTx in patients with end-stage HF related to ischaemic cardiomyopathy (ICM).

中文翻译:


转诊心脏移植评估的终末期心力衰竭患者室性心律失常的预防性导管消融术:CASTLE-VT 试验的基本原理和设计



及时转诊进行移植和左心室辅助装置 (LVAD) 对晚期心力衰竭 (HF) 患者的良好预后起着关键作用。由心源性猝死驱动的心血管死亡率是等待心脏移植 (HTx) 期间死亡的主要原因。预防性导管消融术治疗心脏移植评估 (CASTLE-VT) 患者的室性心律失常患者导管消融术的目的是检验致心律失常性瘢痕组织的预防性导管消融术将降低死亡率、LVAD 植入需求和紧急 HTx 与缺血性心肌病 (ICM) 相关的终末期 HF 患者。
更新日期:2024-11-12
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