A visible-light-promoted protocol for azaspirocyclic synthesis from N-benzylacrylamides and alkyl chlorooxoacetates has been established. This cascade reaction proceeds through sequential free radical addition, cyclization, and dearomatization, enabling the convenient construction of key azaspirocyclic derivatives and the introduction of valuable ester groups in a single step. In addition, this transformation demonstrates broad substrate compatibility and high tolerance toward different functional groups, showcasing remarkable efficiency in functional group insertion and bond formation.

中文翻译：

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光诱导 Ag 介导的氮杂环化方法涉及环化和脱芳烃化


已经建立了从 N-苄基丙烯酰胺和氯氧基乙酸烷基酯合成氮杂环的可见光促进方案。该级联反应通过连续的自由基加成、环化和脱芳烃化进行，从而能够方便地构建关键的氮杂环衍生物，并在一个步骤中引入有价值的酯基。此外，这种转化表现出广泛的底物相容性和对不同官能团的高耐受性，在官能团插入和键形成方面表现出卓越的效率。