A highly efficient iodide ion (I^–)-promoted method for direct α-C(sp²)–H triazolization of aldehydes has been developed for the regioselective synthesis of N²-substituted triazole derivatives. The developed method features the corresponding products in good yields (up to 99%) with an excellent functional group tolerance via an intermolecular oxidative radical coupling. Experimental mechanistic investigations indicate that the reaction proceeds via an I^–-promoted synergistic desulfonylation process, which provides a high regioselectivity. The developed method provides a direct, metal-free, operationally simple, and highly regioselective approach to C(sp²)–H triazolization from easily accessible aldehydes in air.

中文翻译：

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碘离子促进的醛类高区域选择性三唑化，通过脱磺化相关的直接自由基偶联


已经开发了一种用于醛的直接 α-C（sp²）–H 三唑化的高效碘离子 （I^–） 促进方法，用于 N²-取代的三唑衍生物的区域选择性合成。开发的方法通过分子间氧化自由基偶联获得相应的产物，产率高（高达 99%），具有出色的官能团耐受性。实验机理研究表明，反应^{通过 I 促进}的协同脱磺酰化过程进行，该过程提供了高区域选择性。开发的方法提供了一种直接、无金属、操作简单且高度区域选择性的方法，可从空气中易于接近的醛中进行 C（sp²）-H 三唑化反应。