An iodine-mediated electrochemical four-component reaction was developed to construct aromatic C–N bonds by making use of a simple nitrogen source, such as NH₄⁺ and formamide. By virtue of this reaction, a variety of benzoxazoles bearing different substituents can be selectively modulated by using different bases. This protocol features a broad substrate scope and good scalability, is transition metal-free and chemical oxidant-free, and exhibits controlled product distribution. Additionally, it also enables a versatile platform for various isotope-labeled (¹⁵N and CD₃) benzoxazoles.

中文翻译：

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通过碘介导的电化学四组分反应将多个氮源精确掺入苯并恶唑中


开发了一种碘介导的电化学四组分反应，利用简单的氮源（如 NH₄⁺ 和甲酰胺）构建芳香族 C-N 键。通过该反应，可以使用不同的碱选择性地调节各种带有不同取代基的苯并恶唑。该协议具有广泛的底物范围和良好的可扩展性，不含过渡金属和化学氧化剂，并表现出受控的产品分布。此外，它还为各种同位素标记（¹⁵N 和 CD₃）苯并恶唑提供了一个多功能平台。