The development of coreaction accelerators with excellent performance is crucial for improving electrochemiluminescence (ECL) performance. In this study, a NiFe nanoalloy electrocatalyst (NiFe-NAEC) was used as a coreaction accelerator to promote persulfate activation, resulting in a 44-fold increase in the ECL intensity of flower-like Zn-3,4,9,10-perylenetetracarboxylate (FL-Zn-PTC). Moreover, the synergistic combination of NiFe-NAEC and silver nanoparticles led to a 134-fold increase in the ECL intensity of FL-Zn-PTC, with a 6275% improvement in the ECL efficiency compared with a reference system containing Ru-bpy/K₂S₂O₈. Consequently, a sensor was constructed for the visual detection of amino-terminal pro-brain natriuretic peptide. This sensor exhibited high sensitivity and provided intuitive results within a linear range from 0.01 to 1000 pg/mL, with a detection limit of 2.1 fg/mL. Overall, this study presents a strategy that integrates an electrocatalytic coreaction accelerator with synergistic enhancement to improve ECL performance. This approach has the potential to expand the range of emitter materials and advance ECL technology.

中文翻译：

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NiFe 纳米合金电催化剂作为助反应促进剂，用于增强生物标志物电化学发光成像检测


开发性能优异的助反应促进剂对于提高电化学发光 （ECL） 性能至关重要。在本研究中，使用 NiFe 纳米合金电催化剂 （NiFe-NAEC） 作为共反应促进剂以促进过硫酸盐活化，导致花状 Zn-3,4,9,10-苝四羧酸盐 （FL-Zn-PTC） 的 ECL 强度增加了 44 倍。此外，NiFe-NAEC 和银纳米颗粒的协同组合导致 FL-Zn-PTC 的 ECL 强度增加了 134 倍，与含有 Ru-bpy/K₂S₂O₈ 的参比系统相比，ECL 效率提高了 6275%。因此，构建了用于目视检测氨基末端脑利钠肽前体的传感器。该传感器具有高灵敏度，可在 0.01 至 1000 pg/mL 的线性范围内提供直观的结果，检测限为 2.1 fg/mL。总体而言，本研究提出了一种策略，将电催化反应促进剂与协同增强相结合，以提高 ECL 性能。这种方法有可能扩大发射极材料的范围并推进 ECL 技术。