Melanoma brain metastasis is associated with high morbidity and mortality and remains a major clinical challenge. Despite recent successes with combination immune checkpoint inhibitors (ICI) in the treatment of affected patients, the mechanistic underpinnings of T cell entry and response to these drugs in brain metastasis are poorly understood. Using real-time intravital microscopy, Messmer and colleagues identified peritumoral venous vessels (PVVs) as critical sites for T cell entry into brain metastases, a process accelerated by ICI treatment. The expression of intercellular adhesion molecule 1 (ICAM-1) on PVVs was found to be important for T cell recruitment in pre-clinical models and associated with increased T cell infiltration in human brain metastatic lesions. This study highlights PVVs as key vascular entry points for T cells into brain metastases, laying the foundation for enhancing the efficacy of cancer immunotherapies.

中文翻译：

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腹周静脉血管：T 细胞到黑色素瘤脑转移的 Autobahn 和 Portal


黑色素瘤脑转移与高发病率和死亡率相关，仍然是一个主要的临床挑战。尽管最近联合免疫检查点抑制剂 （ICI） 在治疗受影响患者方面取得了成功，但对脑转移中 T 细胞进入和对这些药物的反应的机制基础知之甚少。使用实时活体显微镜，Messmer 及其同事确定瘤周静脉血管 （PVV） 是 T 细胞进入脑转移瘤的关键部位，ICI 治疗加速了这一过程。发现 PVV 上细胞间粘附分子 1 （ICAM-1） 的表达对临床前模型中的 T 细胞募集很重要，并且与人脑转移病灶中 T 细胞浸润的增加有关。本研究强调 PVV 是 T 细胞进入脑转移瘤的关键血管切入点，为增强癌症免疫疗法的疗效奠定了基础。