The uMI Panorama GS PET/CT system is a new long-axial-field-of-view scanner featuring high sensitivity, time-of-flight (TOF) resolution, spatial resolution, and count rate performance. The aim of this study is to assess the PET system on the basis of the National Electrical Manufacturers Association (NEMA) NU 2-2018 and European Association of Nuclear Medicine Research Limited (EARL) standards. Methods: Spatial resolution, count rate performance, sensitivity, accuracy, image quality, TOF resolution, and coregistration accuracy were evaluated following the NEMA NU 2-2018 standard. Additional experiments included energy resolution, 200-cm-long line sources for sensitivity, a 175-cm-long scatter phantom for count rate and TOF resolution, as well as the compliance with the EARL guideline. Moreover, an ¹⁸F-FDG PET patient study was reconstructed with various frame durations. Results: The PET system achieved sub–3-mm transaxial and axial spatial resolutions at a 1-cm radial offset. The sensitivities with the 70-cm-long and 200-cm-long line sources were observed to be 176.3 and 90.8 kcps/MBq, respectively, at the center of the field of view. The noise-equivalent count rates (NECRs) of the 70-cm-long and 175-cm-long scatter phantoms were measured to be 3.35 Mcps at 57.57 kBq/mL and 2.24 Mcps at 33.27 kBq/mL, respectively. The TOF resolutions for both phantoms were approximately 189 ps at 5.3 kBq/mL and lower than 200 ps below the NECR peaks. The absolute count rate errors of all 34 acquisitions were less than 3% below the NECR peak for the 70-cm-long scatter phantom. With the standard NEMA image quality phantom experiment, the contrast recovery coefficient varied from 68.17% to 94.20% and the background variabilities were all below 2%. The maximum PET/CT coregistration error was 1.33 mm. Regarding EARL compliance, the gaussian filter of 5-mm full width at half maximum could produce acceptable images. The patient data demonstrate visually satisfactory image quality with short frames (less than 1 min). Conclusion: The uMI Panorama GS exhibits spatial resolution and TOF resolution similar to those of the uMI Panorama system (35-cm axial field of view), despite the extended axial field of view. The 148-cm axial coverage, sub–200-ps TOF resolution, high sensitivity, and count rate performances are expected to yield superior image quality and offer new opportunities for various clinical applications.

uMI Panorama GS PET/CT 系统是一款新型长轴视场扫描仪，具有高灵敏度、飞行时间 （TOF） 分辨率、空间分辨率和计数率性能。本研究的目的是根据美国国家电气制造商协会 （NEMA） NU 2-2018 和欧洲核医学研究协会有限公司 （EARL） 标准评估 PET 系统。方法：按照 NEMA NU 2-2018 标准评估空间分辨率、计数率性能、灵敏度、准确性、图像质量、TOF 分辨率和共配准准确性。其他实验包括能量分辨率、200 厘米长的线源灵敏度、用于计数率和 TOF 分辨率的 175 厘米长的散射体模，以及符合 EARL 指南。此外，以不同的帧持续时间重建了一项 ¹⁸F-FDG PET 患者研究。结果：PET 系统在 1 cm 径向偏移处实现了亚 3 mm 的跨轴和轴向空间分辨率。在视场中心观察到 70 cm 长和 200 cm 长的线源的灵敏度分别为 176.3 和 90.8 kcps/MBq。70 cm 长和 175 cm 长散射模型的噪声等效计数率 （NECRs） 在 57.57 kBq/mL 时分别为 3.35 Mcps，在 33.27 kBq/mL 时为 2.24 Mcps。两种体型的 TOF 分离度在 5.3 kBq/mL 时约为 189 ps，低于 NECR 峰 200 ps。所有 34 次采集的绝对计数率误差均比 70 cm 长散射模型的 NECR 峰低 3% 以下。在标准 NEMA 图像质量体模实验中，对比度恢复系数从 68.17% 到 94.20% 不等，背景变化率均低于 2%。 最大 PET/CT 同配误差为 1.33 mm。关于 EARL 合规性，半高 5 毫米全宽的高斯滤波器可以产生可接受的图像。患者数据在短帧（少于 1 分钟）下表现出令人满意的视觉图像质量。结论：uMI Panorama GS 表现出与 uMI Panorama 系统（35 cm 轴向视野）相似的空间分辨率和 TOF 分辨率，尽管轴向视野扩大。148 cm 轴向覆盖、低于 200 ps TOF 的分辨率、高灵敏度和计数率性能有望产生卓越的图像质量，并为各种临床应用提供新的机会。