Intracellular dark endothelial spots (IDESs) on specular microscopy developed in 78/122 patients (63.9%) after Descemet stripping automated endothelial keratoplasty (DSAEK). Endothelial cell density (ECD) after DSAEK was significantly smaller in eyes with IDES when compared with those without at all time points (p<0.001) despite no significant difference in graft ECD (p=0.43), resulting in an increased rate of endothelial failure (p=0.044). The presence of glaucoma (OR=2.22, p=0.027), iris damage (OR=2.85, p=0.004) and non-Fuchs status (OR=2.37, p=0.018) were identified as risk factors for IDES development. Preoperative total protein level in aqueous humour was significantly higher in eye with endothelial failure than those without (p=0.0057). The data that support the findings of this study are available on request from the corresponding author (TY). The data are not publicly available due to them containing information that could compromise research participant privacy/consent.

中文翻译：

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细胞内黑斑与 Descemet 剥离自动角膜内皮移植术后的内皮细胞丢失有关


镜面显微镜下镜面显微镜下出现细胞内暗内皮斑点 （IDES） 的患者 78/122 例 （63.9%） 后后弹力层剥离自动内皮角膜移植术 （DSAEK）。尽管移植物 ECD 无显著差异 （p=0.43），但与无 IDES 的眼睛相比，有 IDES 的眼睛 DSAEK 后内皮细胞密度 （ECD） 显着减小 （p<0.001），导致内皮衰竭率增加 （p=0.044）。青光眼 （OR=2.22，p=0.027）、虹膜损伤 （OR=2.85，p=0.004） 和非 Fuchs 状态 （OR=2.37，p=0.018） 被确定为 IDES 发生的危险因素。内皮衰竭眼术前房水总蛋白水平显著高于无内皮衰竭的眼 （p=0.0057）。支持本研究结果的数据可应通讯作者 （TY） 的要求提供。这些数据不公开，因为它们包含可能损害研究参与者隐私/同意的信息。