The fMRI study conducted by Gifuni et al. [1] investigates neural responses during social inclusion/exclusion tasks in suicide attempters compared to psychiatric and healthy controls. The authors highlight a significant finding regarding lower activation in the left insula during inclusion vs. control condition (i.e. passive viewing or implicit social exclusion (ISE)), in suicide attempters compared to the control groups. Additionally, they report that higher perception of social exclusion (measured by Need Threat Scale) is correlated with insular activity during inclusion-control contrast. Two critical observations merit consideration in light of these results for further investigation.

Firstly, the decreased insula activation in suicide attempters may be associated with a general processing of negative states rather than a specific impact of social exclusion. Indeed, perception of social exclusion is correlated with insular activity but also with level of depression. Interestingly Caceda et al. [2] found a significant correlation between anterior insula response during inclusion-rest and depression severity.

Gifuni 等人 [1] 进行的 fMRI 研究调查了与精神病学和健康对照相比，自杀未遂者在社会包容/排斥任务期间的神经反应。作者强调了一个重要的发现，即与对照组相比，自杀未遂者在纳入条件下（即被动观看或隐性社交排斥 （ISE））左岛的激活较低。此外，他们报告说，在包容-控制对比期间，较高的社会排斥感知（通过需求威胁量表衡量）与孤立活动相关。鉴于这些结果，两个关键观察结果值得考虑，以便进一步调查。

首先，自杀未遂者岛叶激活减少可能与消极状态的一般处理有关，而不是社会排斥的特定影响。事实上，对社会排斥的看法与孤立活动有关，但也与抑郁程度有关。有趣的是，Caceda 等人 [2] 发现包涵体-休息期间的前岛叶反应与抑郁严重程度之间存在显着相关性。