Lactate was once considered as metabolic waste for a long time. In 2019, Professor Zhao Yingming’s team from the University of Chicago found that lactate could also be used as a substrate to induce histone lactylation and regulate gene expression. Since then, researchers have discovered that lactate-mediated lactylation play important regulatory roles in various physiological and pathological processes.

中文翻译：

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乳酸介导的乳酸化在人类健康和疾病中的研究进展和仍然存在的挑战


乳酸长期以来一直被认为是代谢废物。2019 年，芝加哥大学赵英明教授团队发现，乳酸也可以作为底物诱导组蛋白乳酸化和调节基因表达。从那时起，研究人员发现乳酸介导的乳酸化在各种生理和病理过程中起着重要的调节作用。