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Financial suppport

The research of the authors is supported in part by grants from the German Federal Ministry of Health (BMG), the Ministry of Culture and Science of the State North Rhine Westphalia (MKW NRW) to DDZ, and the German Federal Ministry of Education and Research (BMBF) and the MKW NRW to German Center for Diabetes Research (DZD e. V.). The research of M.R. is supported by grants from the European Community (HORIZON-HLTH-2022-STAYHLTH-02-01: Panel A) to the INTERCEPT-T2D consortium, the German Science

Author contributions

S.K. drafted the manuscript. S.K. and M.R. revised and approve the final version of the manuscript. M.R. is the guarantor of this work, with full access to all data and analyses related to the content of this article.

ClinTrials.gov identifier

NCT01477957We thank Xiyin Yang and Qiang Hu for their interest in our article [1], which investigated the association of whole-body insulin sensitivity and hepatic OXPHOS capacity in people with obesity grade 3. We would like to take the opportunity to address their comments on our study.First, the prospective BARIA-DDZ study was designed to assess metabolic changes with one focus on different features of hepatic mitochondrial function in people with obesity. For this purpose, we developed a

Declaration of Competing Interest

M.R. received lecture fees or served on advisory boards for AstraZeneca, Echosens, Eli Lilly, Madrigal, Merck-MSD, Novo Nordisk and Target RWE and performed investigator-initiated research with support from Boehringer Ingelheim, Novo Nordisk and Nutricia/Danone to the German Diabetes Center (DDZ). No conflicts of interest, financial or otherwise, are declared by the other authors.

中文翻译：

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血糖异常和肝脂含量影响肥胖患者胰岛素抵抗与肝脏线粒体功能之间的联系 – 作者回复

 部分片段

 财务支持

作者的研究部分得到了德国联邦卫生部 （BMG）、北莱茵-威斯特法伦州文化和科学部 （MKW NRW） 对 DDZ 以及德国联邦教育和研究部 （BMBF） 和 MKW NRW 对德国糖尿病研究中心 （DZD e. V.） 的资助。M.R. 的研究得到了欧洲共同体 （HORIZON-HLTH-2022-STAYHLTH-02-01： Panel A） 对 INTERCEPT-T2D 联盟、德国科学的资助

 作者贡献

S.K. 起草了手稿。S.K. 和 M.R. 修订并批准了手稿的最终版本。M.R. 是这项工作的保证人，可以完全访问与本文内容相关的所有数据和分析。

ClinTrials.gov 标识符

NCT01477957我们感谢 Xiyin Yang 和 Qiang 胡 对我们的文章 [1] 的兴趣，该文章调查了 3 级肥胖患者全身胰岛素敏感性与肝脏 OXPHOS 能力的关联。我们想借此机会回应他们对我们研究的评论。首先，前瞻性 BARIA-DDZ 研究旨在评估代谢变化，重点关注肥胖患者肝脏线粒体功能的不同特征。为此，我们开发了一种

利益争夺声明

M.R. 为阿斯利康、Echosens、礼来、Madrigal、默克-默沙东、诺和诺德和塔吉特 RWE 收取讲座费或在顾问委员会任职，并在勃林格殷格翰、诺和诺德和纽迪希亚/达能的支持下进行研究者发起的研究到德国糖尿病中心 （DDZ）。其他作者未声明任何利益冲突，无论是财务还是其他方面。