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Quantitative phase imaging endoscopy with a metalens
Light: Science & Applications ( IF 20.6 ) Pub Date : 2024-11-08 , DOI: 10.1038/s41377-024-01587-y
Aamod Shanker, Johannes E. Fröch, Saswata Mukherjee, Maksym Zhelyeznyakov, Steven L. Brunton, Eric J. Seibel, Arka Majumdar

Quantitative phase imaging (QPI) recovers the exact wavefront of light from intensity measurements. Topographical and optical density maps of translucent microscopic bodies can be extracted from these quantified phase shifts. We demonstrate quantitative phase imaging at the tip of a coherent fiber bundle using chromatic aberrations inherent in a silicon nitride hyperboloid metalens. Our method leverages spectral multiplexing to recover phase from multiple defocus planes in a single capture using a color camera. Our 0.5 mm aperture metalens shows robust quantitative phase imaging capability with a \({28}^{\circ}\) field of view and 0.\({2}{\pi}\) phase resolution ( ~ 0.\({1}{\lambda}\) in air) for experiments with an endoscopic fiber bundle. Since the spectral functionality is encoded directly in the imaging lens, the metalens acts both as a focusing element and a spectral filter. The use of a simple computational backend will enable real-time operation. Key limitations in the adoption of phase imaging methods for endoscopy such as multiple acquisition, interferometric alignment or mechanical scanning are completely mitigated in the reported metalens based QPI.



中文翻译:


使用超透镜的定量相位成像内窥镜检查



定量相位成像 (QPI) 从强度测量中恢复光的精确波前。可以从这些量化的相移中提取半透明微观体的形貌和光密度图。我们展示了使用氮化硅双曲面超透镜中固有的色差在相干纤维束尖端进行定量相位成像。我们的方法利用光谱多路复用,使用彩色相机在单次捕获中从多个散焦平面恢复相位。我们的 0.5 mm 孔径超透镜显示出强大的定量相位成像能力,视野为 \({28}^{\circ}\) 和 0.\({2}{\pi}\) 相位分辨率 ( ~ 0.\({1}{\lambda}\) 在空气中)进行内窥镜纤维束实验。由于光谱功能直接编码在成像镜头中,因此超透镜既充当聚焦元件,又充当光谱滤光片。使用简单的计算后端将实现实时操作。在报道的基于超透镜的 QPI 中,完全缓解了采用相位成像方法进行内窥镜检查的主要限制,例如多次采集、干涉对准或机械扫描。

更新日期:2024-11-08
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