The liver injury diseases caused by multiple factors have attracted widespread attention and good monitoring strategies are essential in the treatment process. In the past few decades, optical imaging techniques including fluorescence imaging, photoacoustic imaging and magnetic resonance imaging were gradually mastered and applied in clinical diagnosis and treatment of liver injury diseases. Such imaging techniques depend on probes generating signals in response to the critical biomarkers in liver injury diseases, and then the signals can be detected by corresponding instruments. Among them, we consider that nanoprobes with excellent aqueous solubility and biocompatibility have better application prospects. In this review, we focused on discussing the common design strategies, targeted biomarkers, detecting principles and biological applications of nanoprobes that have been developed, and we hope this review can inspire the development of nanoprobes utilized in the field of liver injury treatment.

中文翻译：

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基于光学成像技术的纳米探针，用于检测肝损伤疾病中的生物标志物


由多种因素引起的肝损伤疾病引起了广泛关注，良好的监测策略在治疗过程中至关重要。近几十年来，包括荧光成像、光声成像和磁共振成像在内的光学成像技术逐渐被掌握并应用于肝损伤疾病的临床诊断和治疗。这种成像技术依赖于探针产生信号以响应肝损伤疾病中的关键生物标志物，然后这些信号可以被相应的仪器检测到。其中，我们认为具有优异水溶性和生物相容性的纳米探针具有更好的应用前景。在这篇综述中，我们重点讨论了已经开发的纳米探针的常见设计策略、靶向生物标志物、检测原理和生物学应用，我们希望这篇综述可以激发用于肝损伤治疗领域的纳米探针的发展。