Herein, we demonstrate the ability of isonitriles to be used as alkyl radical precursors in a photoredox-catalyzed transformation involving selective C–N cleavage and Csp³–Csp² bond formation. This protocol allows for the preparation of functionalized heteroarenes from readily available isonitriles through a decyanation process. The reaction is general for primary, secondary, and tertiary substrates, including amino acid derivatives and druglike molecules.

中文翻译：

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异腈和（杂）芳烃通过光氧化还原催化的双脱氰过程的 Csp3–Csp2 偶联


在此，我们证明了异腈在光氧化还原催化转化中用作烷基自由基前体的能力，涉及选择性 C-N 切割和 Csp^{3-Csp 2} 键形成。该方案允许通过脱氰工艺从现成的异腈制备功能化的杂芳烃。该反应通常适用于一级、二级和三级底物，包括氨基酸衍生物和药物样分子。