Dementia prevention in Africa is critically underexplored, despite the continent's high prevalence of modifiable risk factors. With a predominantly young and middle-aged population, Africa presents a prime opportunity to implement evidence-based strategies that could significantly reduce future dementia cases and mitigate its economic impact. The multinational Africa-FINGERS program offers an innovative solution, pioneering culturally sensitive, multidomain interventions tailored to the unique challenges of the region. Leveraging insights from landmark global studies such as Worldwide-FINGERS and Alzheimer's Disease Neuroimaging Initiative, the program employs a multideterminant precision prevention framework, grounded in community based systems dynamics. Africa-FINGERS further integrates cutting-edge state-of-the-art multimodal biomarker evaluations tailored to regional contexts, with the goal of advancing brain health and establishing a global standard for dementia prevention. This groundbreaking initiative highlights the potential for scalableand sustainable interventions, thus is poised to transform dementia risk reduction efforts across the continent.

中文翻译：

---

在非洲背景下降低痴呆症风险：多国实施多模式战略以促进非洲健康的大脑衰老（Africa-FINGERS 项目）


尽管非洲大陆可改变的风险因素非常普遍，但非洲的痴呆症预防研究严重不足。非洲以年轻人和中年人口为主，为实施循证战略提供了绝佳的机会，这些战略可以显着减少未来的痴呆病例并减轻其经济影响。多国 Africa-FINGERS 计划提供了一种创新的解决方案，开创了针对该地区独特挑战量身定制的文化敏感、多领域干预措施。利用来自 Worldwide-FINGERS 和阿尔茨海默病神经影像学计划等具有里程碑意义的全球研究的见解，该计划采用基于社区的系统动力学的多行定因素精确预防框架。Africa-FINGERS进一步整合了针对区域环境量身定制的尖端最先进的多模式生物标志物评估，目的是促进大脑健康和建立预防痴呆的全球标准。这一开创性的举措凸显了可扩展和可持续干预措施的潜力，因此有望改变整个非洲大陆的痴呆风险降低工作。