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In cystic fibrosis (CF), Pseudomonas aeruginosa acquisition represents a turning point in disease progression. The presence of chronic P. aeruginosa infection is associated with worsening lung function and increased risk of earlier death, whereas treatment substantially improves lung function and survival [1, 2]. Efforts to diagnose and eradicate early P. aeruginosa provide lasting benefits for children with CF [3, 4]. However, the timing of infection varies considerably between individuals with CF, treatment centres [5, 6], and different birth cohorts of people with the disease [7, 8].

中文翻译：

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解码囊性纤维化中铜绿假单胞菌感染的遗传易感性

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在囊性纤维化 （cystic fibrosis， CF） 中，铜绿假单胞菌的获得代表了疾病进展的转折点。慢性铜绿假单胞菌感染与肺功能恶化和早期死亡风险增加有关，而治疗可显著改善肺功能和生存率 [1， 2]。诊断和根除早期铜绿假单胞菌的努力为 CF 儿童提供了持久的益处 [3， 4]。然而，CF 患者、治疗中心 [5， 6] 和不同的出生队列 [7， 8] 之间的感染时间差异很大。