Notch signaling is a highly conserved pathway activated by dynamic cellular interactions that initiates a molecular cascade that ultimately drives changes in gene expression. The Notch transcriptional complex (NTC) regulates genes that influence development and homeostasis. In this issue of Genes & Development, Rogers and colleagues (doi:10.1101/gad.352108.124) leverage a rapid Notch activation system combined with molecular genomic profiling to reveal that the NTC regulates the release of paused RNA polymerase to activate direct target genes. They also highlight the role of the SWI/SNF chromatin remodeling complex in establishing and maintaining chromatin accessibility to potentiate the activation of NTC target genes.

中文翻译：

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对转录因子的分子功能进行分类，超越激活和抑制


Notch 信号转导是一种由动态细胞相互作用激活的高度保守的通路，可启动分子级联反应，最终驱动基因表达的变化。Notch 转录复合物 （NTC） 调节影响发育和体内平衡的基因。在本期的基因与发展中，罗杰斯及其同事（doi：10.1101/gad.352108.124）利用快速Notch激活系统结合分子基因组分析揭示NTC调节暂停的RNA聚合酶的释放以激活直接目标基因。他们还强调了 SWI/SNF 染色质重塑复合物在建立和维持染色质可及性以增强 NTC 靶基因激活方面的作用。