Circadian desynchrony induced by shiftwork or jet lag is detrimental to metabolic health, but how synchronous or desynchronous signals are transmitted among tissues is unknown. We report that liver molecular clock dysfunction is signaled to the brain through the hepatic vagal afferent nerve (HVAN), leading to altered food intake patterns that are corrected by ablation of the HVAN. Hepatic branch vagotomy also prevents food intake disruptions induced by high-fat diet feeding and reduces body weight gain. Our findings reveal a homeostatic feedback signal that relies on communication between the liver and the brain to control circadian food intake patterns. This identifies the hepatic vagus nerve as a potential therapeutic target for obesity in the setting of chronodisruption.

中文翻译：

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肝脏迷走神经传入神经传递时钟依赖性信号以调节昼夜节律食物摄入


轮班工作或时差引起的昼夜节律不同步对代谢健康有害，但同步或同步信号如何在组织之间传递尚不清楚。我们报道，肝脏分子钟功能障碍通过肝迷走神经传入神经 （HVAN） 向大脑发出信号，导致食物摄入模式改变，这些改变可通过 HVAN 消融来纠正。肝支迷走神经切断术还可以防止高脂肪饮食喂养引起的食物摄入中断，并减少体重增加。我们的研究结果揭示了一种稳态反馈信号，它依赖于肝脏和大脑之间的通信来控制昼夜节律食物摄入模式。这确定了肝迷走神经在时间中断的情况下是肥胖的潜在治疗靶点。