Cartilage degradation is a critical alteration in the progression of osteoarthritis (OA) due to the disorder of chondrocyte metabolic homeostasis. Autophagy plays an important role in maintaining intracellular homeostasis. Recent investigations have increasingly underscored the importance of autophagy in modulating the pathological mechanisms underlying OA. Ras-related protein Rab-1a (Rab1a) has been illustrated to regulate autophagy in many diseases but not in OA.

中文翻译：

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Rab1a 增加通过激活 mTORC1-S6K 通路抑制自噬，从而加速骨关节炎


软骨降解是由于软骨细胞代谢稳态障碍引起的骨关节炎 （OA） 进展的关键改变。自噬在维持细胞内稳态中起重要作用。最近的研究越来越强调自噬在调节 OA 病理机制中的重要性。Ras 相关蛋白 Rab-1a （Rab1a） 已被证明在许多疾病中调节自噬，但在 OA 中则不调节。