The extracellular matrix (ECM) serves as a physical scaffold for tissues that is composed of structural proteins such as laminins, collagens, proteoglycans and fibronectin, forming a three dimensional network, and a wide variety of other matrix proteins with ECM-remodeling and signaling functions. The activity of ECM-associated signaling proteins is tightly regulated. Thus, the ECM serves as a reservoir for water and growth regulatory signals. The ECM architecture is dynamically modulated by multiple serine proteases that process both structural and signaling proteins to regulate physiological processes such as organogenesis and tissue homeostasis but they also contribute to pathological events, especially cancer progression. Here, we review the current literature regarding the role of ECM remodeling by serine proteases (KLKs, uPA, furin, HtrAs, granzymes, matriptase, hepsin) in tumorigenesis.

中文翻译：

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通过丝氨酸蛋白酶重塑细胞外基质是癌症发生和进展的先决条件


细胞外基质 （ECM） 作为组织的物理支架，由层粘连蛋白、胶原蛋白、蛋白聚糖和纤连蛋白等结构蛋白组成，形成三维网络，以及具有 ECM 重塑和信号转导功能的各种其他基质蛋白。ECM 相关信号转导蛋白的活性受到严格调节。因此，ECM 充当水和生长调节信号的储存库。ECM 结构受多种丝氨酸蛋白酶的动态调节，这些蛋白酶处理结构蛋白和信号蛋白以调节器官发生和组织稳态等生理过程，但它们也有助于病理事件，尤其是癌症进展。在这里，我们回顾了目前关于丝氨酸蛋白酶 （KLK、uPA、弗林蛋白酶、HtrAs、颗粒酶、马曲他酶、肝蛋白酶） 在肿瘤发生中的作用的文献。