Background Left ventricular mass (LVM) is an established marker of cardiovascular risk; however, long-term follow-up studies in individuals with low to intermediate risk are lacking. Purpose To assess the sex-specific association of LVM measured with cardiac MRI with cardiovascular outcomes in those with a less than 20% 10-year risk of cardiovascular disease (CVD). Materials and Methods A total of 1528 volunteers older than 40 years of age with no history of CVD, a 10-year risk of CVD of less than 20%, and a B-type natriuretic peptide level greater than their sex-specific median underwent cardiac MRI between June 2008 and February 2013 as part of the Tayside Screening for Cardiac Events, or TASCFORCE, prospective study. LVM was indexed to body surface area, and the LVM-to-volume ratio was calculated. Follow-up for cardiovascular events was performed using national electronic health records. Cox proportional hazard models and Kaplan-Meier curves were applied to assess the impact of LVM. Results A total of 1495 participants (mean age, 54.5 years ± 8.3 [SD]; 925 female, 570 male) completed cardiac MRI, with a median follow-up of 10 years (IQR, 3 years). In female participants, LVM was associated with age, blood pressure, smoking status, and cholesterol level, while in male participants, LVM was associated with age and blood pressure. In female participants, the LVM-to-volume ratio was associated with cardiovascular events (hazard ratio [HR], 2.3 [95% CI: 1.1, 4.9] for the highest quartile vs the lowest quartile), while the LVM was not. In male participants, the LVM was associated with cardiovascular events (HR, 3.2 [95% CI: 1.5,7.0] for the highest quartile vs the lowest quartile), while the LVM-to-volume ratio was not. Conclusion In those with low to intermediate risk without established CVD, different remodeling patterns predict cardiovascular events, with increased LVM predictive in male participants, while LVM-to-volume ratio is predictive in female participants. © RSNA, 2024 Supplemental material is available for this article. See also the editorial by Garot and Duhamel in this issue.

中文翻译：

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MRI 左心室重塑与长期心血管风险之间的性别特异性关联。


背景 左心室质量 （LVM） 是心血管风险的既定标志物;然而，缺乏对低至中等风险个体的长期随访研究。目的 评估心脏 MRI 测量的 LVM 与心血管疾病 （CVD） 10 年风险低于 20% 的人群的心血管结局的性别特异性关联。材料和方法 共有 1528 名 40 岁以上、无 CVD 病史、10 年心血管疾病风险低于 20% 且 B 型利钠肽水平大于其性别特异性中位数的志愿者在 2008 年 6 月至 2013 年 2 月期间接受了心脏 MRI，作为 Tayside 心脏事件筛查的一部分， 或 TASCFORCE，前瞻性研究。将 LVM 与体表面积为指数，并计算 LVM 与体积的比率。使用国家电子健康记录对心血管事件进行随访。应用 Cox 比例风险模型和 Kaplan-Meier 曲线来评估 LVM 的影响。结果 共有 1495 名参与者 （平均年龄 54.5 岁 ± 8.3 [SD];925 名女性，570 名男性）完成了心脏 MRI，中位随访时间为 10 年 （IQR，3 年）。在女性参与者中，LVM 与年龄、血压、吸烟状况和胆固醇水平相关，而在男性参与者中，LVM 与年龄和血压相关。在女性参与者中，LVM 与体积比与心血管事件相关（风险比 [HR]，最高四分位数与最低四分位数为 2.3 [95% CI： 1.1， 4.9]），而 LVM 则不然。在男性参与者中，LVM 与心血管事件相关 （HR，最高四分位数与最低四分位数的 HR，3.2 [95% CI： 1.5,7.0]），而 LVM 与体积比则不相关。 结论 在未确诊 CVD 的中低风险患者中，不同的重塑模式可预测心血管事件，男性参与者的 LVM 预测性增加，而女性参与者的 LVM 与体积比可预测。© RSNA，2024 年本文提供补充材料。另请参见本期 Garot 和 Duhamel 的社论。