We developed siRNA-loaded anionic liposomes, co-encapsulating low-dose amphotericin B, to enhance siRNA penetration through the fungal cell wall of Aspergillus fumigatus. Targeting mRNAs of three key genes, these liposomes visibly inhibited fungal growth, demonstrating for the first time the antifungal potential of siRNA against human fungal pathogens.

中文翻译：

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增强载有 siRNA 的阴离子脂质体对人病原真菌烟曲霉的抗真菌活性


我们开发了载有 siRNA 的阴离子脂质体，共包封低剂量两性霉素 B，以增强 siRNA 通过烟曲霉真菌细胞壁的渗透。这些脂质体靶向三个关键基因的 mRNA，明显抑制了真菌生长，首次证明了 siRNA 对人类真菌病原体的抗真菌潜力。