We read with interest the findings by Zhou et al that identified the microbiota-induced S100A11-RAGE axis as a basis for immune evasion in proximal colorectal cancer (CRC), the targeting potential of this pathway in enhancing the efficacy of anti-PD-1 therapy.1 Currently, despite showing a response more favourably in hypermutated tumours, the effectiveness of immunotherapy in microsatellite stable CRC patients remains controversial, largely due to the imprecision in defining the subset of patients who benefit.2 The authors addressed CRC in different anatomical locations, focusing on different anatomical subsites, where microsatellite instability (MSI) represents one of the key molecular distinctions. However, the underlying causes of the differential MSI patterns between anatomical sites and the development of precise, effective therapies targeting MSI remain unclear.3 The present study did not investigate whether distinct microbial communities might …

中文翻译：

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微生物对微卫星不稳定性的潜在影响可能导致不同解剖亚位点之间结直肠癌免疫治疗反应的分歧


我们饶有兴趣地阅读了 周 等人的发现，该发现确定了微生物群诱导的 S100A11-RAGE 轴是近端结直肠癌 （CRC） 免疫逃避的基础，该途径在增强抗 PD-1 治疗疗效方面的靶向潜力。目前，尽管在高突变肿瘤中显示出更有利的反应，但免疫疗法对微卫星稳定 CRC 患者的有效性仍然存在争议， 主要是由于定义受益患者子集的不精确性.2 作者讨论了不同解剖位置的 CRC，重点关注不同的解剖亚位点，其中微卫星不稳定性 （MSI） 代表了关键的分子区别之一。然而，解剖部位之间 MSI 模式差异的根本原因以及针对 MSI 的精确、有效疗法的开发仍不清楚.3 本研究没有调查不同的微生物群落是否可能......