Since the concept of metal ion stimulation-mediated chemodynamic therapy was proposed by Bu and Shi's group in 2016, increasing attention has been directed toward the fabrication of efficient, safe and stable Fenton/Fenton-like catalysts to advance clinical translation. In particular, metal-based complexes with inherent metal catalytic centers have received extensive attention as potential alternatives/complements for traditional CDT agents. Among them, copper-based complexes, which possess excellent redox properties, extensive adaptability and abundant availability, enable the efficient generation of ROS through Fenton-like reactions in CDT, thereby causing oxidative damage to lipids, proteins, and DNA in cancer cells. In this brief review, we summarize the recent progress on various discrete copper-based metal complexes aimed at enhancing the therapeutic efficacy of CDT as well as their application in combination therapy. We hope that this review will attract active attention toward metal complexes in advancing more accurate and efficient chemodynamic therapy and encourage further in-depth research to facilitate clinical translation.

中文翻译：

---

离散 Cu 配合物在增强化学动力学治疗中的最新进展


自 Bu 和 Shi 的小组于 2016 年提出金属离子刺激介导的化学动力学疗法的概念以来，人们越来越关注制造高效、安全和稳定的 Fenton/Fenton 样催化剂以推进临床转化。特别是，具有固有金属催化中心的金属基配合物作为传统 CDT 试剂的潜在替代品/补充而受到广泛关注。其中，铜基复合物具有优异的氧化还原性能、广泛的适应性和丰富的可用性，能够通过 CDT 中的 Fenton 样反应高效生成 ROS，从而对癌细胞中的脂质、蛋白质和 DNA 造成氧化损伤。在这篇简短的综述中，我们总结了各种离散的铜基金属络合物的最新进展，旨在提高 CDT 的治疗效果及其在联合治疗中的应用。我们希望本综述将引起对金属络合物的积极关注，以推进更准确和有效的化学动力学治疗，并鼓励进一步深入研究以促进临床转化。