We show that PEG-induced macromolecular crowding enhances protein detection in nanopores by increasing capture rate and translocation frequency. Experimental data indicate that a PEG concentration gradient boosts capture efficiency, while our theoretical model attributes this enhancement to osmotic flow, offering insights for improving nanopore-based biosensing.

中文翻译：

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改善纳米孔中的大分子拥挤构型以用于蛋白质传感


我们表明 PEG 诱导的大分子拥挤通过提高捕获速率和易位频率来增强纳米孔中的蛋白质检测。实验数据表明，PEG 浓度梯度提高了捕获效率，而我们的理论模型将这种增强归因于渗透流，为改进基于纳米孔的生物传感提供了见解。