A number of therapeutics that target mediators of signalling in the hypothalamic and brainstem regions that control appetite, ingestive behaviour, satiety, nausea and vomiting are starting to move the needle on cancer cachexia. However, clarification of meaningful clinical benefits for patients and the primary end points that should support regulatory approval of cachexia treatments is needed.

中文翻译：

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在癌症恶病质靶向治疗的风口浪尖上 — 我们可以向患者承诺哪些临床益处？


许多针对控制食欲、摄入行为、饱腹感、恶心和呕吐的下丘脑和脑干区域信号介质的疗法开始对癌症恶病质产生影响。然而，需要阐明对患者有意义的临床益处以及应支持监管部门批准恶病质治疗的主要终点。