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Ancient and versatile CRISPR–Cas nuclease created with ancestral sequence reconstruction
Nature Biotechnology ( IF 33.1 ) Pub Date : 2024-11-05 , DOI: 10.1038/s41587-024-02468-w


Ancestral sequence reconstruction enables the identification and synthesis of ReChb, an ancient form of CRISPR–Cas12a with a highly versatile functionality. ReChb can target any nucleic acid, with minimal restrictions, making it a multipurpose tool for genome editing and genetic diagnostics.

中文翻译:


通过祖先序列重建创建的古老且多功能的 CRISPR-Cas 核酸酶



祖先序列重建能够鉴定和合成 ReChb,ReChb 是一种古老的 CRISPR-Cas12a 形式,具有高度通用的功能。ReChb 可以靶向任何核酸,限制最小,使其成为基因组编辑和遗传诊断的多用途工具。
更新日期:2024-11-05
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