Macrophage activation syndrome (MAS) is a state of immune hyperactivation that can result in life‐threatening multisystem end‐organ dysfunction. Often termed a “cytokine storm”, MAS occurs among the rheumatic diseases most typically in Still's disease but also in systemic lupus erythematosus and Kawasaki disease. MAS can also accompany infection, malignancy, and inborn errors of immunity. This review provides a practical, evidence‐based guide to the understanding, recognition, and management of MAS in children and adults, with a primary focus on MAS complicating Still's disease.

中文翻译：

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巨噬细胞活化综合征


巨噬细胞活化综合征 （MAS） 是一种免疫过度激活状态，可导致危及生命的多系统终末器官功能障碍。MAS 通常被称为“细胞因子风暴”，是风湿性疾病中的代表之一，最典型的是斯蒂尔病，但也存在于系统性红斑狼疮和川崎病中。MAS 还可能伴有感染、恶性肿瘤和先天性免疫缺陷。本综述为理解、识别和管理儿童和成人的 MAS 提供了实用的、循证的指南，主要关注 MAS 使斯蒂尔病复杂化。