Integrins are cellular transmembrane receptors that physically connect the cytoskeleton with the extracellular matrix. As such, they are positioned to mediate cellular responses to microenvironmental cues. Importantly, integrins also regulate their own microenvironment through secreted factors, also known as the integrin-mediated secretome. Epidermal integrins, or integrins expressed by keratinocytes of the skin epidermis, regulate the cutaneous microenvironment through the contribution of matrix components, via proteolytic matrix remodeling, or by mediating factors like cytokines and growth factors that can promote support for nearby but distinct cells of the stroma, such as immune cells, endothelial cells, and fibroblasts. This role for integrins is enhanced during both pathological and repair tissue remodeling processes, such as tumor growth and progression and wound healing. This review will discuss examples of how the epithelial integrin-mediated secretome can regulate the tissue microenvironment. Although different epithelial integrins in various contexts will be explored, emphasis will be given to epidermal integrins that regulate the secretome during wound healing and cutaneous tumor progression. Epidermal integrin α3β1 is of particular focus as well, since this integrin has been revealed as a key regulator of the keratinocyte secretome.

中文翻译：

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表皮整合素介导的分泌组在肿瘤发生和修复过程中调节皮肤微环境


整合素是细胞跨膜受体，可将细胞骨架与细胞外基质物理连接。因此，它们被定位于介导细胞对微环境线索的反应。重要的是，整合素还通过分泌因子调节自身的微环境，也称为整合素介导的分泌组。表皮整合素或皮肤表皮角质形成细胞表达的整合素通过基质成分的贡献、通过蛋白水解基质重塑或通过介导细胞因子和生长因子等因子来调节皮肤微环境，这些因子可以促进对附近但不同的基质细胞的支持，例如免疫细胞、内皮细胞和成纤维细胞。整合素的这种作用在病理和修复组织重塑过程中都得到增强，例如肿瘤生长和进展以及伤口愈合。本文将讨论上皮整合素介导的分泌组如何调节组织微环境的示例。尽管将探索不同情况下的不同上皮整合素，但将重点放在伤口愈合和皮肤肿瘤进展过程中调节分泌组的表皮整合素。表皮整合素 α3β1 也特别受到关注，因为该整合素已被揭示为角质形成细胞分泌组的关键调节因子。