In the complex human body fluids, neurotransmitters such as dopamine (DA) play a significant role in regulating physiological functions, thereby impacting the normal functioning of biological activities. Hence, employing a rapid and non-destructive analytical technique for precise measurement of these molecules is crucial. Here, a novel piezoelectric-enhanced ZnO/Ag microcavity SERS substrate was designed, enabling ultra-sensitive and instantaneous detection of DA molecules. This substrate achieves exceptional trace detection performance, with a detection limit for Rhodamine 6 G (R6G) molecules as low as 5×10−13 M and a EF of 1.05×1011, DA can be accurately identified even at exceedingly low concentrations, demonstrating outstanding capabilities in trace detection. This innovative structure not only represents a breakthrough in the rapid trace detection of neurotransmitters but also introduces new avenues for research and diagnostics in fields such as precision medicine, neuroscience, and pharmaceutical development.

中文翻译：

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用于多巴胺检测的压电增强超灵敏 ZnO/Ag 微腔 SERS 底物


在复杂的人体体液中，多巴胺 （DA） 等神经递质在调节生理功能方面发挥着重要作用，从而影响生物活动的正常功能。因此，采用快速无损的分析技术来精确测量这些分子至关重要。在这里，设计了一种新型压电增强 ZnO/Ag 微腔 SERS 衬底，能够对 DA 分子进行超灵敏和瞬时检测。该底物实现了出色的痕量检测性能，对罗丹明 6 G （R6G） 分子的检测限低至 5×10−13 M，EF 为 1.05×1011，即使在极低的浓度下也能准确识别 DA，表现出出色的痕量检测能力。这种创新结构不仅代表了神经递质快速痕量检测的突破，还为精准医学、神经科学和药物开发等领域的研究和诊断开辟了新的途径。