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TRPM2-mediated feed-forward loop promotes chondrocyte damage in osteoarthritis via calcium-cGAS-STING-NF-κB pathway
Journal of Advanced Research ( IF 11.4 ) Pub Date : 2024-11-05 , DOI: 10.1016/j.jare.2024.11.007 Kai Sun, Xiong Zhang, Liangcai Hou, Fan Lu, Haigang Liu, Zehang Zheng, Zhou Guo, Jingting Xu, Zhaoxuan Ruan, Yanjun Hou, Junchen He, Fengjing Guo, Kaixiang Yang
Journal of Advanced Research ( IF 11.4 ) Pub Date : 2024-11-05 , DOI: 10.1016/j.jare.2024.11.007 Kai Sun, Xiong Zhang, Liangcai Hou, Fan Lu, Haigang Liu, Zehang Zheng, Zhou Guo, Jingting Xu, Zhaoxuan Ruan, Yanjun Hou, Junchen He, Fengjing Guo, Kaixiang Yang
Osteoarthritis (OA) is a significant contributor to disability in the elderly population. However, current therapeutic options are limited. The transient receptor potential melastatin 2 (TRPM2) is involved in a range of disease processes, yet its role in OA remains unclear.
中文翻译:
TRPM2 介导的前馈环通过钙-cGAS-STING-NF-κB 通路促进骨关节炎软骨细胞损伤
骨关节炎 (OA) 是导致老年人群残疾的重要因素。然而,目前的治疗选择是有限的。瞬时受体电位美拉他汀 2 (TRPM2) 参与一系列疾病过程,但其在 OA 中的作用仍不清楚。
更新日期:2024-11-05
中文翻译:
TRPM2 介导的前馈环通过钙-cGAS-STING-NF-κB 通路促进骨关节炎软骨细胞损伤
骨关节炎 (OA) 是导致老年人群残疾的重要因素。然而,目前的治疗选择是有限的。瞬时受体电位美拉他汀 2 (TRPM2) 参与一系列疾病过程,但其在 OA 中的作用仍不清楚。