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TRPM2-mediated feed-forward loop promotes chondrocyte damage in osteoarthritis via calcium-cGAS-STING-NF-κB pathway
Journal of Advanced Research ( IF 11.4 ) Pub Date : 2024-11-05 , DOI: 10.1016/j.jare.2024.11.007
Kai Sun, Xiong Zhang, Liangcai Hou, Fan Lu, Haigang Liu, Zehang Zheng, Zhou Guo, Jingting Xu, Zhaoxuan Ruan, Yanjun Hou, Junchen He, Fengjing Guo, Kaixiang Yang

Osteoarthritis (OA) is a significant contributor to disability in the elderly population. However, current therapeutic options are limited. The transient receptor potential melastatin 2 (TRPM2) is involved in a range of disease processes, yet its role in OA remains unclear.

中文翻译:


TRPM2 介导的前馈环通过钙-cGAS-STING-NF-κB 通路促进骨关节炎软骨细胞损伤



骨关节炎 (OA) 是导致老年人群残疾的重要因素。然而,目前的治疗选择是有限的。瞬时受体电位美拉他汀 2 (TRPM2) 参与一系列疾病过程,但其在 OA 中的作用仍不清楚。
更新日期:2024-11-05
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