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Tetrahydrocurcumin targets TRIP13 inhibiting the interaction of TRIP13/USP7/c-FLIP to mediate c-FLIP ubiquitination in triple-negative breast cancer
Journal of Advanced Research ( IF 11.4 ) Pub Date : 2024-11-05 , DOI: 10.1016/j.jare.2024.11.004
Yu-jie Sun, Qiang Zhang, Shi-jie Cao, Xiao-hu Sun, Ji-chao Zhang, Bing-yang Zhang, Ze-bin Shang, Chong-yan Zhao, Zhi-yong Cao, Qiu-ju Zhang, Xiu-mei Gao, Feng Qiu, Ning Kang

Triple-negative breast cancer (TNBC) has a high mortality rate and limited treatment options. Tetrahydrocurcumin (THC), a major metabolite of curcumin, has potential antitumor activities. However, the antitumor effects and mechanism of THC in TNBC remain elusive.

中文翻译:


四氢姜黄素靶向 TRIP13,抑制 TRIP13/USP7/c-FLIP 介导三阴性乳腺癌中 c-FLIP 泛素化



三阴性乳腺癌 (TNBC) 死亡率高,治疗选择有限。四氢姜黄素 (THC) 是姜黄素的主要代谢产物,具有潜在的抗肿瘤活性。然而,THC 在 TNBC 中的抗肿瘤作用和机制仍然难以捉摸。
更新日期:2024-11-05
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