A palladium-catalyzed cascade decarboxylative cyclization of alkyne-tethered aryl iodides with o-bromobenzoic acids has been disclosed, which provides a straightforward entry to a range of fused isoquinolinone derivatives. The transformation involves cascade syn-carbopalladation, C–H activation, and a decarboxylation sequence, enabling the simultaneous formation of three C–C bonds. Furthermore, 8-bromo-1-naphthoic acid can act as a viable substrate to forge a seven-membered ring fused isoquinolinone.

中文翻译：

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钯催化炔烃系芳基碘化物与邻溴苯甲酸的级联脱羧环化反应，用于合成熔融异喹啉烯


已经公开了炔烃-拴系芳基碘化物与邻溴苯甲酸的钯催化级联脱羧环化反应，这为一系列熔融异喹啉酮衍生物提供了直接的入口。转化涉及级联 syn-carbopalladation、C-H 激活和脱羧序列，从而能够同时形成三个 C-C 键。此外，8-溴-1-萘甲酸可以作为活的底物来锻造七元环熔融异喹啉酮。