The enantioselective reactivity of 3-hydroxyquinolin-2(1H)-ones was developed through their addition to isatin and pyrazole-4,5-dione derived ketimines, affording novel architectures featuring multiple natural product scaffolds in high yields with excellent enantioselectivities. Gram-scale synthesis and synthetic transformations further disclosed the potential of the current process.

中文翻译：

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将 3-羟基喹啉-2（1H）-酮对映选择性添加到靛红和吡唑-4,5-二酮衍生的酮胺中


3-羟基喹啉-2（1H）-酮的对映选择性反应性是通过添加到骰红素和吡唑-4,5-二酮衍生的酮胺中开发的，从而提供了具有多个天然产物支架的新型结构，产量高，具有优异的对映选择性。克级合成和合成转化进一步揭示了当前过程的潜力。