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Focused Ultrasound Pallidothalamic Tractotomy in Cervical Dystonia: A Pilot Study
Movement Disorders ( IF 7.4 ) Pub Date : 2024-11-02 , DOI: 10.1002/mds.30030
Shiro Horisawa, Ryo Saito, Bohui Qian, Hiroki Hori, Kilsoo Kim, Masato Murakami, Toru Kakegawa, Keiichi Abe, Atsushi Fukui, Kotaro Kohara, Mutsumi Iijima, Takakazu Kawamata, Takaomi Taira

BackgroundNo clinical trials have been reported on the use of focused ultrasound (FUS) for treating cervical dystonia.ObjectiveWe aimed to confirm the efficacy and safety of FUS pallidothalamic tractotomy for cervical dystonia.MethodsThis was a prospective, open‐label, non‐controlled pilot study. The primary outcome was defined as a change in the score for the Toronto Western Spasmodic Torticollis Rating Scale (TWSTRS) from baseline to 6 months after FUS pallidothalamic tractotomy. The secondary outcomes included a change in the neck scale for the Burke‐Fahn‐Marsden Dystonia Rating Scale (BFMDRS), mood scales including Beck Depression Inventory (BDI), Beck Anxiety Inventory (BAI), Apathy Evaluating Scale (AES), and adverse events. Patients were assessed for TWSTRS, BFMDRS, and adverse events at baseline, 1 week, 1 month, 3 months, and 6 months after treatment. BDI, BAI, and AES were assessed at baseline and 6 months after treatment.ResultsTen patients were enrolled in this study. The mean age of onset of dystonia was 51.6 ± 10.2 years. The TWSTRS at 6 months (29.9 ± 16.0, range: 3–55) was significantly improved by 43.4% (P < 0.001) from baseline. The BFMDRS‐Neck scales at 6 months (4.2 ± 2.8) were significantly improved by 38.2% (P < 0.001) from baseline. The BDI, BAI, and AES at 6 months were improved by 23.2%, 10.9%, and 30.3%, respectively from baseline. Reduced hand dexterity in three patients and weight gain in two patients were confirmed at the last evaluation.ConclusionThis study suggests that FUS pallidothalamic tractotomy may be an effective treatment option for patients with cervical dystonia. © 2024 International Parkinson and Movement Disorder Society.

中文翻译:


颈部肌张力障碍的聚焦超声腭丘脑束切开术:一项初步研究



背景尚无关于使用聚焦超声 (FUS) 治疗颈部肌张力障碍的临床试验报道。目的我们旨在确认 FUS 苍白丘脑束切开术治疗颈部肌张力障碍的有效性和安全性。方法这是一项前瞻性、开放标签、非对照的试点研究。主要结局定义为多伦多西部痉挛斜颈评定量表 (TWSTRS) 评分从基线到 FUS 苍丘脑束切开术后 6 个月的变化。次要结局包括 Burke-Fahn-Marsden 肌张力障碍评定量表 (BFMDRS) 颈部量表的变化,情绪量表包括贝克抑郁量表 (BDI) 、贝克焦虑量表 (BAI) 、情感淡漠评估量表 (AES) 和不良事件。在基线、治疗后 1 周、1 个月、3 个月和 6 个月评估患者的 TWSTRS 、 BFMDRS 和不良事件。在基线和治疗后 6 个月评估 BDI 、 BAI 和 AES。结果10 例患者入组本研究。肌张力障碍的平均发病年龄为 51.6 ± 10.2 岁。6 个月时的 TWSTRS (29.9 ± 16.0,范围:3-55) 比基线显着改善了 43.4% (P < 0.001)。6 个月时 BFMDRS-Neck 量表 (4.2 ± 2.8) 较基线显著改善 38.2% (P < 0.001)。6 个月时的 BDI 、 BAI 和 AES 较基线分别提高了 23.2% 、 10.9% 和 30.3%。在最后一次评估中证实了 3 名患者的手部灵活性降低和 2 名患者的体重增加。结论本研究表明,FUS 苍丘脑束切开术可能是颈部肌张力障碍患者的有效治疗选择。© 2024 年国际帕金森和运动障碍协会。
更新日期:2024-11-02
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