BackgroundThe cerebellar cognitive affective syndrome (CCAS) encompasses cognitive and affective symptoms in patients with cerebellar disorders, for which no proven treatment is available.ObjectivesOur primary objective was to study the effect of cerebellar anodal transcranial direct current stimulation (tDCS) on cognitive performance in CCAS patients. Secondary effects on ataxia severity, mood, and quality of life were explored.MethodsWe performed a randomized, double‐blind, sham‐controlled trial. Thirty‐five patients with CCAS were included and received 10 sessions of 20 minutes sham (n = 17) or real (n = 18) tDCS, with a current of 2 mA. Cognitive performance was assessed using executive function subtests of the computerized Test of Attentional Performance (TAP), with the composite as primary endpoint. Secondary outcomes were ataxia severity, mood, and quality of life. Outcomes were evaluated 1, 3, 6, and 12 months post‐intervention.ResultsCerebellar tDCS was well tolerated and no serious adverse events related to the intervention occurred. No significant tDCS effect was found on cognitive performance. Improvement on the TAP was observed in the sham group 1 month post‐treatment (estimate = −0.248, 95% CI, −0.49 to −0.01), but not clinically relevant. A positive tDCS effect was observed for ataxia severity 1 month post‐treatment (estimate = −0.985, 95% CI, −1.94 to −0.03).ConclusionsTen sessions of 20 minutes cerebellar anodal tDCS did not prove efficacious for CCAS‐related cognitive impairment, but a significant positive effect of tDCS was found for ataxia severity, aligning with previous findings indicative of tDCS as a therapeutic neuromodulation tool in cerebellar disorders. © 2024 The Author(s). Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.

中文翻译：

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小脑认知情感综合征中的小脑经颅直流电刺激：一项随机、双盲、假对照试验


背景小脑认知情感综合征 （CCAS） 包括小脑疾病患者的认知和情感症状，目前尚无经过验证的治疗方法。目的我们的主要目的是研究小脑阳极经颅直流电刺激 （tDCS） 对 CCAS 患者认知能力的影响。探讨了对共济失调严重程度、情绪和生活质量的次要影响。方法我们进行了一项随机、双盲、假对照试验。纳入 35 例 CCAS 患者，接受 10 次 20 分钟的假 （n = 17） 或真实 （n = 18） tDCS，电流为 2 mA。使用计算机化注意力表现测试 （TAP） 的执行功能子测试评估认知能力，以综合为主要终点。次要结局是共济失调的严重程度、情绪和生活质量。在干预后 1 、 3 、 6 和 12 个月评估结果。结果小脑 tDCS 耐受性良好，未发生与干预相关的严重不良事件。未发现 tDCS 对认知能力有显着影响。在治疗后 1 个月，假手术组观察到 TAP 的改善 （估计 = -0.248,95% CI，-0.49 至 -0.01），但无临床相关性。治疗后 1 个月观察到共济失调严重程度的阳性 tDCS 效应 （估计 = -0.985,95% CI，-1.94 至 -0.03）。结论10 次 20 分钟的小脑阳极 tDCS 未被证明对 CCAS 相关的认知障碍有效，但发现 tDCS 对共济失调严重程度有显着的积极影响，与先前的发现一致，表明 tDCS 作为小脑疾病的治疗性神经调控工具。© 2024 作者。 由 Wiley Periodicals LLC 代表国际帕金森和运动障碍协会出版的《运动障碍》。