The development of inflammation has an indispensable importance in the self-protection of the human body. However, over-inflammation may damage human health, and inflammatory pathways and inflammasomes have a significant impact on the onset of inflammation. Therefore, how to constrain the development of inflammation through inflammatory pathways or inflammasomes becomes a hot research issue. Carotenoids are a natural pigment and an active substance in algae, with anti-inflammatory and antioxidant effects. Many studies have shown that carotenoids have inhibitory effects on the inflammatory pathways and inflammasomes. In this review, we discussed the mechanism of carotenoids targeting those important inflammatory pathways and their effects on common inflammasome NLRP3 and inflammation-related diseases from the perspective of several inflammatory pathways, including p38 MAPK, IL-6/JAK/STAT3, and PI3K, with a focus on the targets and targeting effects of carotenoids on different inflammatory signaling pathways, and at last proposed possible anti-inflammatory targets.

中文翻译：

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藻类类胡萝卜素对炎症信号通路影响的研究进展


炎症的发展在人体的自我保护中具有不可或缺的重要性。然而，过度炎症可能会损害人体健康，而炎症途径和炎症小体对炎症的发生有重大影响。因此，如何通过炎症途径或炎性小体限制炎症的发展成为研究热点。类胡萝卜素是一种天然色素，也是藻类中的活性物质，具有抗炎和抗氧化作用。许多研究表明，类胡萝卜素对炎症途径和炎性小体具有抑制作用。本文从p38 MAPK、IL-6/JAK/STAT3和PI3K等几种炎症途径的角度讨论了类胡萝卜素靶向这些重要炎症途径的机制及其对常见炎性小体NLRP3和炎症相关疾病的影响，重点介绍了类胡萝卜素对不同炎症信号通路的靶向和靶向作用，最后提出了可能的抗炎靶点。