Summary: Despite an increasingly detailed understanding of cancer hallmarks at molecular or atomic resolution, most studies, however, fall short of investigating the systemic interactions of cancer with the human body. We propose to investigate the hallmarks of cancer from an organ-wide macroscopic view, discuss the challenges in preclinical and clinical research to study the cross-organ regulation of cancer together with potential directions to overcome these challenges, and foresee how this holistic view may be translated into more effective therapies.

中文翻译：

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构建癌症标志物的器官范围宏观视图


摘要： 尽管在分子或原子分辨率下对癌症标志的了解越来越详细，但大多数研究都未能调查癌症与人体的全身相互作用。我们建议从器官范围的宏观角度研究癌症的特征，讨论临床前和临床研究中研究癌症跨器官调控的挑战以及克服这些挑战的潜在方向，并预见这种整体观点如何转化为更有效的疗法。