Summary: The conventional wisdom is that the overwhelming majority of neoantigens arise from chromosomal DNA mutations; however, recent studies show that posttranscriptional and posttranslational events can also generate neoantigens. This commentary provides an overview of known and potential sources of nonchromosomal neoantigens, emerging technologies, and clinical trials that may move this field forward to redefine immunologically “hot/cold” tumors and develop next-generation immunotherapeutic approaches.

中文翻译：

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表面之下：染色体 DNA 突变之外的新抗原


摘要： 传统观点认为，绝大多数新抗原是由染色体DNA突变引起的;然而，最近的研究表明，转录后和翻译后事件也可以产生新抗原。本评论概述了非染色体新抗原的已知和潜在来源、新兴技术和临床试验，这些技术可能会推动该领域向前发展，以重新定义免疫学上的“热/冷”肿瘤并开发下一代免疫治疗方法。