Summary: Annual low-dose CT screening of individuals with a smoking history identifies early curable lung tumors and reduces cancer mortality by 20%, yet only a minority of eligible patients undergo such monitoring. Mazzone and colleagues apply a blood-based cfDNA fragmentomic assay as a high-sensitivity/low-specificity pre-screen to help stratify individuals who may benefit most from more definitive low-dose CT imaging. See related article by Mazzone et al., p. 2224

中文翻译：

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联合诊断：在低剂量 CT 成像中加入基于血液的 ctDNA 筛查以早期发现肺癌


摘要： 对有吸烟史的个体进行年度低剂量 CT 筛查可识别早期可治愈的肺肿瘤，并将癌症死亡率降低 20%，但只有少数符合条件的患者接受了此类监测。Mazzone 及其同事将基于血液的 cfDNA 片段组学检测作为高灵敏度/低特异性的预筛查，以帮助对可能从更明确的低剂量 CT 成像中受益最多的个体进行分层。参见 Mazzone 等人的相关文章，第 2224 页