Summary: Significant efforts have been made to identify and validate oncoproteins and ncRNAs as therapeutic targets for cancer therapy; however, emerging observations suggest that noncoding cis-regulatory elements, which orchestrate the 3D organization of the genome and thus the transcriptional landscape, are potential therapeutic targets as well. In this commentary, we envisage that further efforts to decipher the noncoding cis-regulatory code and performing systematic surveys of functional noncoding cis-regulatory elements and recurrent 3D genome alterations in both cancerous and nonmalignant cells within tumor tissues will pave the way to the development of novel therapeutic strategies.

中文翻译：

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在 3D 基因组的背景下靶向癌症治疗的非编码顺式调节元件


摘要： 已经做出了重大努力来鉴定和验证癌蛋白和 ncRNAs 作为癌症治疗的治疗靶点;然而，新出现的观察结果表明，协调基因组 3D 组织从而协调转录景观的非编码顺式调节元件也是潜在的治疗靶点。在本评论中，我们设想进一步努力破译非编码顺式调节密码，并对肿瘤组织内癌性和非恶性细胞中的功能性非编码顺式调节元件和复发性 3D 基因组改变进行系统调查，这将为开发新的治疗策略铺平道路。