BackgroundHigh positivity rate of skin phosphorylated α‐synuclein (P‐SYN) was observed in Parkinson's disease (PD). Bullous pemphigoid (BP) is one of the most common autoimmune skin diseases associated with PD.ObjectivesOur aim was to investigate whether BP patients might be a targeted risk population for the screening of skin P‐SYN.MethodsSkin P‐SYN expression was evaluated by immunohistochemistry in BP patients with/without PD.ResultsTwenty‐two BP patients with PD, 24 BP patients without PD, and seven healthy donors were enrolled. Colocalization of P‐SYN and PGP9.5 was found in all BP patients, but only one healthy control, whereas BP patients with PD showed higher expression than BP patients without PD (mean ± standard deviation, 10.7 ± 6.7 vs. 7.3 ± 3.2; P = 0.027). Positive expression was mainly observed in basement membrane zone and dermis.ConclusionThese results indicated BP patients might be a targeted risk population for the screening of skin P‐SYN, which was helpful for the detection of PD early. © 2024 The Author(s). Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.

中文翻译：

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伴或不伴帕金森病的大疱性类天疱疮患者磷酸化 α-突触核蛋白的皮肤活检检测


背景在帕金森病 （PD） 中观察到皮肤磷酸化 α-突触核蛋白 （P-SYN） 阳性率高。大疱性类天疱疮 （BP） 是与 PD 相关的最常见的自身免疫性皮肤病之一。目的我们的目的是调查 BP 患者是否可能是皮肤 P-SYN 筛查的目标风险人群。方法通过免疫组化评估 BP 伴/不伴 PD 患者的皮肤 P-SYN 表达。结果纳入 22 例 BP 合并 PD 患者，24 例无 PD 的 BP 患者和 7 名健康供体。在所有 BP 患者中发现 P-SYN 和 PGP9.5 共定位，但只有一个健康对照，而有 PD 的 BP 患者表现出比无 PD 的 BP 患者更高的表达 （平均±标准差，10.7 ± 6.7 vs. 7.3 ± 3.2;P = 0.027）。阳性表达主要在基底膜区和真皮中观察到。结论这些结果提示 BP 患者可能是皮肤 P-SYN 筛查的目标风险人群，有助于早期发现 PD。© 2024 作者。由 Wiley Periodicals LLC 代表国际帕金森和运动障碍协会出版的《运动障碍》。