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High precision acoustofluidic synthesis of stable, biocompatible water-in-water emulsions
Ultrasonics Sonochemistry ( IF 8.7 ) Pub Date : 2024-10-23 , DOI: 10.1016/j.ultsonch.2024.107120
Kajal Sharma, Hao Deng, Parikshit Banerjee, Zaimao Peng, Jackson Gum, Alberto Baldelli, Jacek Jasieniak, Laurence Meagher, Mikaël M. Martino, Venkat Gundabala, Tuncay Alan

Water-in-water (w/w) emulsions, comprising aqueous droplets within another continuous aqueous phase, rely on a low interfacial tension for stability. Thus far, it has been challenging to control their size and stability without the use of stabilizers. In this study, we introduce a microfluidic technique that addresses these challenges, producing stable w/w emulsions with precisely controlled size and uniformity. Results shows that using an acoustically actuated microfluidic mixer, PEG, Dextran, and alginate solutions (84.66 mPa.s viscosity difference) were homogenized rapidly, forming uniformly distributed w/w emulsions stabilized in alginate gels.

中文翻译:


高精度声流合成稳定、生物相容性的水包水乳液



水包水 (w/w) 乳液由另一个连续水相中的水液滴组成,依靠低界面张力来实现稳定性。到目前为止,在不使用稳定器的情况下控制它们的大小和稳定性一直是一个挑战。在这项研究中,我们介绍了一种解决这些挑战的微流体技术,生产出具有精确控制和均匀性的稳定 w/w 乳液。结果表明,使用声驱动微流体混合器,PEG、葡聚糖和藻酸盐溶液 (粘度差 84.66 mPa.s) 迅速均质化,形成均匀分布的 w/w 乳液,稳定在藻酸盐凝胶中。
更新日期:2024-10-23
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