In recent years, viral infections such as COVID-19, Zika virus, Nipah virus, Ebola, Influenza, Monkeypox, and Dengue have substantially impacted global health. These outbreaks have led to heightened global health initiatives and collaborative efforts to address and mitigate these significant threats effectively. Thus, developing antiviral treatments and research in this field has become highly important. Heterocycles, particularly indole motifs, have been a valuable resource in drug discovery, as they can be used as treatments or inspire the synthesis of new potent candidates. Indole-containing drugs, such as enfuvirtide (T-20), arbidol, and delavirdine, have demonstrated significant efficacy in treating viral diseases. This review aims to comprehensively assess the latest research and developments in novel indoles as potential scaffolds for antiviral activity. We have compiled detailed information about indoles as potential antivirals by conducting a thorough literature survey from the past ten years. The review includes discussions on synthetic protocols, inhibitory concentrations, SAR study, and computational study. This review shall identify new antiviral indoles that may help to combat new viral threats in the future.

中文翻译：

---

关于吲哚作为药物发现中特权抗病毒支架的最新报道


近年来，COVID-19、寨卡病毒、尼帕病毒、埃博拉病毒、流感、猴痘和登革热等病毒感染对全球健康产生了重大影响。这些疫情导致全球卫生倡议和协作努力加强，以有效应对和减轻这些重大威胁。因此，开发该领域的抗病毒治疗和研究变得非常重要。杂环，尤其是吲哚基序，一直是药物发现的宝贵资源，因为它们可以用作治疗或激发新的有效候选药物的合成。含吲哚的药物，如 enfuvirtide （T-20）、arbidol 和 delavirdine，在治疗病毒性疾病方面已显示出显着疗效。本综述旨在全面评估新型吲哚作为抗病毒活性潜在支架的最新研究和发展。我们通过对过去十年进行全面的文献调查，汇编了有关吲哚作为潜在抗病毒药物的详细信息。本综述包括对合成方案、抑制浓度、SAR 研究和计算研究的讨论。该审查将确定可能有助于对抗未来新病毒威胁的新型抗病毒吲哚。