Ketone-to-alkene transformations are essential in organic synthesis, and transition-metal-catalyzed cross-coupling reactions involving enol derivatives have become powerful tools to achieve this goal. While substantial progress has been made in nucleophile–electrophile reactions, recent developments in nickel-catalyzed reductive alkenylation reactions have garnered increasing attention. These methods accommodate a broad range of functional groups such as aldehyde, ketone, amide, alcohol, alkyne, heterocycles, and organotin compounds, providing an efficient strategy to access structurally diverse alkenes. This Account primarily highlights the contributions from our laboratory to this growing field while also acknowledging key contributions from other researchers.

中文翻译：

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烯醇衍生物的镍催化还原烯基化反应：烯烃构建的通用工具


酮到烯烃的转化在有机合成中是必不可少的，涉及烯醇衍生物的过渡金属催化的交叉偶联反应已成为实现这一目标的有力工具。虽然亲核-亲电反应取得了实质性进展，但镍催化的还原烯基化反应的最新进展引起了越来越多的关注。这些方法适用于广泛的官能团，如醛、酮、酰胺、醇、炔烃、杂环和有机锡化合物，为获得结构多样的烯烃提供了一种有效的策略。本报告主要突出了我们实验室对这一不断发展的领域的贡献，同时也感谢了其他研究人员的关键贡献。