As clinical psychological science and biological psychiatry push to assess, model, and integrate heterogeneity and individual differences, approaches leveraging computational modeling, translational methods, and dimensional approaches to psychopathology are increasingly useful in establishing brain-behavior relationships. The field is ultimately interested in complex human behavior, and disruptions in such behaviors can arise through many different pathways, leading to heterogeneity in etiology for seemingly similar presentations. Parsing this complexity may be enhanced using "simple" tasks-which we define as those assaying elemental processes that are the building blocks to complexity. Using eyeblink conditioning as one illustrative example, we propose that simple tasks assessing elemental processes can be leveraged by and enhance computational psychiatry and dimensional approaches in service of understanding heterogeneity in psychiatry, especially when these tasks meet three principles: (a) an extensively mapped circuit, (b) clear brain-behavior relationships, and (c) relevance to understanding etiological processes and/or treatment. (PsycInfo Database Record (c) 2024 APA, all rights reserved).

中文翻译：

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评估解析异质性中基本过程的简单任务效用的三个原则。


随着临床心理科学和生物精神病学推动评估、建模和整合异质性和个体差异，利用计算建模、转化方法和精神病理学维度方法的方法在建立大脑-行为关系方面越来越有用。该领域最终对复杂的人类行为感兴趣，而这种行为的中断可以通过许多不同的途径出现，导致看似相似的表现的病因异质性。解析这种复杂性可以通过 “简单 ”任务来增强--我们将其定义为那些分析作为复杂性构建块的基本过程的任务。以眨眼条件反射为例，我们提出评估基本过程的简单任务可以被利用并增强计算精神病学和维度方法，以服务于理解精神病学的异质性，特别是当这些任务满足三个原则时：（a） 广泛映射的回路，（b） 清晰的大脑行为关系，以及 （c） 与理解病因过程和/或治疗的相关性。（PsycInfo 数据库记录 （c） 2024 APA，保留所有权利）。