Internalizing psychopathology is associated with abnormalities in heart rate variability (HRV). Lower HRV that reflects reduced parasympathetic nervous system activity has been observed in depressive and anxiety disorders. Existing studies predominantly used categorical rather than dimensional approaches, the latter of which better addresses clinical comorbidity and heterogeneity. Moreover, there is little evidence on the role of HRV in longitudinal symptom trajectory in adolescents and young adults. The current study examined the association between HRV and internalizing symptom trajectory using a dimensional approach-the tri-level model of depression and anxiety. Adolescents and young adults (N = 362) were recruited in a 3-year longitudinal study, where they completed electrocardiogram recordings and self-report symptom questionnaires. Multilevel modeling was conducted with high-frequency power bands (HF power) of interbeat intervals at baseline as the predictor, and tri-level symptom factors over 3 years as the outcome. HF power significantly predicted the trajectory of the broad General Distress symptom factor, but not the intermediate Fears or Anhedonia-Apprehension symptom factors. Higher HF power was associated with a decline in General Distress over time. This association was held when neuroticism, other tri-level symptom factors, and demographic variables were covaried. That is, greater parasympathetic nervous system activity at baseline was significantly associated with a greater decline in the broad internalizing symptom factor, but not symptom factors that are more specific to depressive or anxiety disorders. Parasympathetic activity, therefore, may be a transdiagnostic biomarker for internalizing symptoms in adolescents and young adults. (PsycInfo Database Record (c) 2024 APA, all rights reserved).

中文翻译：

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心率变异性作为青少年和年轻人跨诊断抑郁和焦虑症状轨迹的生物标志物。


内化精神病理学与心率变异性 （HRV） 异常有关。在抑郁症和焦虑症中观察到反映副交感神经系统活动减少的较低 HRV。现有研究主要使用分类法而不是维度法，后者更好地解决了临床合并症和异质性。此外，几乎没有证据表明 HRV 在青少年和年轻人的纵向症状轨迹中的作用。目前的研究使用维度方法——抑郁和焦虑的三级模型——检查了 HRV 与内化症状轨迹之间的关联。青少年和年轻人 （N = 362） 在一项为期 3 年的纵向研究中被招募，他们完成了心电图记录和自我报告症状问卷。以基线时心跳间歇的高频功率带 （HF 功率） 作为预测因子，以 3 年内的三级症状因素作为结果进行多级建模。HF 功率显著预测了广泛的一般痛苦症状因素的轨迹，但不能预测中间的恐惧或快感缺乏-忧虑症状因素的轨迹。较高的 HF 功率与随着时间的推移而下降的一般痛苦有关。当神经质、其他三级症状因素和人口统计学变量协变时，这种关联成立。也就是说，基线时更大的副交感神经系统活动与广泛的内化症状因素的更大下降显着相关，但与对抑郁症或焦虑症更特异性的症状因素无关。因此，副交感神经活动可能是青少年和年轻人内化症状的跨诊断生物标志物。 （PsycInfo 数据库记录 （c） 2024 APA，保留所有权利）。