Anhedonia emerges during adolescence and is characteristic of severe mental illness (SMI). To understand how anhedonia emerges, changes with time, and relates with other symptoms, there is a need to understand patterns of this symptom's course reflecting change or stability-and associations with clinical symptoms and neural reward circuitry in adolescents at risk of SMI. In total, 113 adolescents at low or high familial risk of developing SMI completed clinical measures at up to five time points across 2 years and functional magnetic resonance imaging scanning during a guessing reward task at baseline. Growth curve analysis was used to determine the trajectory of anhedonia across 2 years, including different phases (consummatory and anticipatory) and their association with clinical features (risk status, average suicidal ideation, and average depression across time) and neural activation in response to rewards (ventral striatum and dorsal medial prefrontal cortex). The findings revealed anhedonia decreased across 2 years. Furthermore, lower depression severity was associated with decreases in anhedonia across 2 years. There were no interactions between neural reward activation and anhedonia slopes in predicting clinical features. Exploratory analyses examining latent classes revealed three trajectory classes of anhedonia across phases. While preliminary, in the low and decreasing consummatory anhedonia trajectory class, there was a positive association between neural activation of the right ventral striatum in response to rewards and depression. Certain patterns of anhedonia development could confer risk or resilience for specific types of psychopathologies. The results are preliminary but do highlight the complexity and heterogeneity in anhedonia development. (PsycInfo Database Record (c) 2024 APA, all rights reserved).

中文翻译：

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具有严重精神疾病跨诊断风险的青少年快感缺乏的两年轨迹：与临床症状和脑症状联系的关联。


快感缺乏出现在青春期，是严重精神疾病 （SMI） 的特征。要了解快感缺乏如何出现、随时间变化以及与其他症状相关，需要了解反映变化或稳定性的症状过程模式，以及与有 SMI 风险的青少年的临床症状和神经奖励回路的关联。总共有 113 名患 SMI 的家族风险低或高的青少年在 2 年内完成了多达 5 个时间点的临床测量，并在基线的猜测奖励任务期间完成了功能性磁共振成像扫描。生长曲线分析用于确定快感缺乏在 2 年内的轨迹，包括不同阶段 （完成和预期） 及其与临床特征 （风险状态、平均自杀意念和随时间变化的平均抑郁） 和响应奖励的神经激活 （腹侧纹状体和背侧内侧前额叶皮层） 的关联。研究结果显示，快感缺乏在 2 年内有所下降。此外，较低的抑郁严重程度与 2 年内快感缺乏的减少有关。在预测临床特征方面，神经奖励激活和快感缺乏斜率之间没有相互作用。检查潜在类别的探索性分析揭示了跨阶段快感缺乏的三个轨迹类别。虽然是初步的，但在低和递减的完满快感缺乏轨迹类别中，响应奖励和抑郁的右腹侧纹状体的神经激活之间存在正相关。某些快感缺乏发展模式可能会为特定类型的精神病理学带来风险或恢复力。结果是初步的，但确实突出了快感缺乏发展的复杂性和异质性。 （PsycInfo 数据库记录 （c） 2024 APA，保留所有权利）。