The wearing of contact lenses (CLs) may cause bacterial infections, leading in turn to more serious complications and ultimately vision impairment. In this scenario, the first step is the adhesion of tear proteins, which provide anchoring points for bacterial colonization. A possible solution is the functionalization with an antimicrobial coating, though the latter may also lead to sight obstruction and user discomfort. In this study, adipic acid dihydrazide-modified hyaluronic acid-cobalt (II) (HA-ADH-Co) nanogels (NGs) were synthesized and deposited onto commercial CLs in a single-step sonochemical process. The coating hindered up to 60 % the protein adsorption and endowed the CLs with strong antibacterial activity against major ocular pathogens like Staphylococcus aureus and Pseudomonas aeruginosa, reducing their concentration by around 3 logs. Cytotoxicity assessment with human corneal cells demonstrated viabilities above 95 %. The nanocomposite coating did not affect the optical power and the light transmission of the CLs and provided enhanced wettability, important for the wearer comfort.

中文翻译：

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抗菌和防污透明质酸-钴纳米凝胶涂层通过声化学方法建立在隐形眼镜上


佩戴隐形眼镜 （CLs） 可能会导致细菌感染，进而导致更严重的并发症，并最终导致视力障碍。在这种情况下，第一步是泪液蛋白的粘附，泪液蛋白为细菌定植提供锚定点。一种可能的解决方案是使用抗菌涂层进行功能化，尽管后者也可能导致视力障碍和用户不适。在这项研究中，合成了己二酸二酰肼修饰的透明质酸-钴 （II） （HA-ADH-Co） 纳米凝胶 （NGs） 并以一步声化学过程沉积在商业 CLs 上。该涂层阻碍了高达 60% 的蛋白质吸附，并赋予 CLs 对金黄色葡萄球菌和铜绿假单胞菌等主要眼部病原体的强大抗菌活性，使其浓度降低了约 3 个对数。人角膜细胞的细胞毒性评估显示活力高于 95%。纳米复合涂层不会影响 CL 的光功率和透光率，并提供了增强的润湿性，这对佩戴者的舒适度很重要。