Noninvasive glucose sensors are emergent intelligent sensors for analyzing glucose concentration in body fluids within invasion-free conditions. Conventional glucose sensors are often limited by a number of issues such as invasive and real-time detection, creating challenges in continuously characterizing biomarkers or subtle binding dynamics. In this study, we introduce an efficient lossy mode resonance (LMR) optical fiber sensor incorporating the molecularly imprinted polymers (MIPs) to amplify glucose molecules. A molecularly imprinted recognition platform is created on an LMR sensor surface through a convenient one-step electrochemical (EC) polymerization method, in which 3-Aminophenylboric acid and glucose serve as the functional monomer and template molecule, respectively. LMR resonance wavelength shift induced by the coupling of the optical lossy mode and the fiber core mode is employed as the parameter to characterize biomolecules. Due to its high sensitivity to surrounding environment changes, a limit of detection (LOD) of 4.62 × 10^–2 μmol/L for glucose can be achieved by this optical fiber sensor. Additionally, the prepared EC-MIPs LMR sensor is capable of detecting glucose molecules in human saliva samples with high accuracy, endowing its potential for practical applications.

中文翻译：

---

电化学分子印迹聚合物增强的有损模式谐振光纤用于葡萄糖检测


无创血糖传感器是新兴的智能传感器，用于在无侵入条件下分析体液中的葡萄糖浓度。传统的葡萄糖传感器通常受到许多问题的限制，例如侵入性和实时检测，从而在持续表征生物标志物或微妙的结合动力学方面带来挑战。在这项研究中，我们介绍了一种高效的有损模式共振 （LMR） 光纤传感器，该传感器结合了分子印迹聚合物 （MIP） 来扩增葡萄糖分子。通过方便的一步电化学 （EC） 聚合方法在 LMR 传感器表面创建分子印迹识别平台，其中 3-氨基苯硼酸和葡萄糖分别作为功能单体和模板分子。采用光有损模式和纤芯模式耦合诱导的 LMR 共振波长偏移作为表征生物分子的参数。由于其对周围环境变化的高度敏感性，该光纤传感器对葡萄糖的检测限 （LOD） 可达 4.62 × 10^–2 μmol/L。此外，制备的 EC-MIPs lmr 传感器能够高精度地检测人体唾液样本中的葡萄糖分子，具有实际应用的潜力。